Fueled by the Pfizer and Allergan megadeal, the healthcare merger and acquisition market set a new record in 2015 even before the end of the year was up. By the end of November, more than $549 billion was spent on healthcare transactions in 1,285 deals, according to data from Irving Levin Associates Inc. That was 42% higher than the previous record set last year, with $387.7 billion spent on 1,312 transactions.

The $160 billion Pfizer-Allergan deal put the total well over 2014’s total—and that deal alone represented 29% of the year’s spending on healthcare transactions. Two other megadeals, the $54.2 billion Anthem-Cigna deal and the $37 billion Aetna-Humana deal, account for 18% of the M&A spending.